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Normal Development Of Cells With Abnormal Numbers Of Nuclei
Most of our cells contain a single nucleus that harbors 46 chromosomes (DNA and protein complexes that contain our genes). However, during normal postnatal development, liver cells containing two nuclei, each of which have 46 chromosomes, appear. These cells, which are known as binucleated tetraploid hepatocytes, arise in all mammals as a result of failure of the cellular process cytokinesis (the process by which the bulk of a cell, excluding the nucleus, divides to form two "daughter" cells). New insight into the failure of this process has now been provided by Chantal Desdouets and colleagues, at Institut Cochin, France, who have identified a cellular signaling pathway that leads to cytokinesis failure and the formation of binucleated tetraploid hepatocytes in rodents.
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Tipper Gore, George Stephanopoulos, Dr. Sanjay Gupta, Richard Gephardt To Appear At Mental Health America's Centennial Conference
Leading mental health advocates and political, medical and policy experts, including Mrs. Tipper Gore, George Stephanopoulos, Dr. Sanjay Gupta and Richard Gephardt, will address the changes and challenges ahead for the mental health field at Mental Health America"s Centennial Conference, June 10-13, in Washington, D.C.
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Salix's Once-Daily APRISO Demonstrates Long-Term Safety In Patients For Maintenance Of Remission From Ulcerative Colitis
Data was announced today that demonstrated Salix Pharmaceuticals" (NASDAQ:SLXP) APRISO™ (mesalamine) 0.375g extended-release capsules had a favorable safety profile in patients in remission from ulcerative colitis (UC) for up to 24 months. APRISO is approved for use up to six months. The majority of treatment-emergent adverse events were mild or moderate in intensity, and were similar to what was seen during the 6-month phase 3 trials. The study, which is the first to examine the long-term safety profile of APRISO, was presented at the Digestive Disease Week (DDW) annual meeting in Chicago, Illinois.
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Economic Downturn Will Have Severe, Far-reaching Effects On Global Health

The health of millions of people worldwide is at risk as a result of the financial crisis, says Dr Andrew Robertson, in an editorial published online in Emerging Health Threats Journal. The world economy is currently in the midst of the most significant recession since the 1930s. The crisis has proved devastating for national economies, and the effects on health care will be felt worldwide as health spending falls, unemployment rises, and international aid is cut. "Health care, already precarious in many developing countries, is likely to decline further as aid dries up and government expenditure falls, with millions more forced into poverty and malnutrition," says Robertson, Director of Disaster Management, Regulation and Planning at the Department of Health for Western Australia, in the article. "The consequences have been seen before." Children, the disabled, and the elderly are likely to be worst hit, particularly in developing countries where poverty and malnutrition will increase demand for already strained health services. Women and girls may also disproportionately suffer. The Asian financial crisis in 1997 saw industries employing women affected first; and spending on women"s health care fell, including antenatal and maternity services. There are concerns that the financial crisis has already hit tuberculosis control, which has global ramifications, says Robertson. "There are already indications that funding for TB diagnosis and management is decreasing in developing countries and a surge of new cases there may flow onto the US and other countries," he says in an associated news article. Healthcare in developed countries will also suffer if budgets are cut and incomes fall. Fewer people are accessing private health services in the USA, which will increase the burden on public health services. Res for disease surveillance are often cut back during difficult economic times, jeopardising the systems we rely on to identify and deal with emerging diseases - including the current swine flu epidemics. The 1995 economic crisis in Mexico led to 27,000 excess deaths in that country alone - but the effect of this far greater, global downturn is currently "impossible to quantify," according to Robertson. Read the full editorial here. The news article on TB is available here. Emerging Health Threats Journal is a peer-reviewed, open access journal published by Emerging Health Threats Forum, focusing on emerging threats to human health from any - including the environment, chemicals, radiation, pathogens, and society. The Journal has a particular focus on the preparedness and response to natural or man-made disasters, including those that involve the deliberate release of chemical, biological, or radionuclear material. Emerging Health Threats Journal


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