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Testosterone Replacement For Men With Low Testosterone Improves Liver Function, Metabolic Syndrome
In middle-aged and older men with low testosterone levels, long-term testosterone replacement therapy greatly improves their fatty liver disease and their risk factors for cardiovascular disease and diabetes, a new study found. The results were presented at The Endocrine Society"s 91st Annual Meeting in Washington, D.C.
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UCLA Scientists Find Molecular Differences Between Embryonic Stem Cells And Reprogrammed Skin Cells
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Sotomayor Resigns From Women's Group
Supreme Court nominee Sonia Sotomayor on Friday resigned from an all-women group in an effort to avoid claims that she belonged to a discriminatory organization, according to a letter she wrote to Senate Judiciary Committee Chair Patrick Leahy (D-Vt.) and ranking member Jeff Sessions (R-Ala.), the Wall Street Journal reports. The group, the Belizean Grove, calls itself a "constellation of influential women" formed in response to the all-male Bohemian Club. Sotomayor wrote, "I believe the Belizean Grove does not practice invidious discrimination, and my membership did not violate the Judicial Code of Ethics, but I do not want questions about this to distract anyone from my qualifications and record." A Senate Republican aide said that GOP members did not plan to object to Sotomayor"s involvement in the group but aimed to compare their position with Democratic objections to previous judicial nominees who were members of all-male groups (Bravin, Wall Street Journal, 6/20).Sotomayor also sent Leahy and Sessions a list of events taken from her own handwritten calendar between 1992 and 1995, which included several entries about events where she spoke. Sessions had told Leahy that he would delay the confirmation proceedings if she did not provide missing information on about 50 speeches she had given. Sotomayor told the senators that she was unable to find drafts or recording of the speeches, noting that her calendar notes did not include details from the speeches (Swanson, The Hill, 6/19).In related news, the New York Times on Saturday examined how "it is far from clear that [Sotomayor"s] judicial record supports the accusation that she is an activist," who, as some critics have claimed, "legislates from the bench." According to the Times, "[s]everal empirical studies have concluded that she is not particularly prone to overriding policy decisions by elected branches." Her decisions that have "attracted the most criticism from conservatives" are "instances in which she deferred to policy decisions by elected branches that conservatives hoped judges would strike down," according to the Times (Savage, New York Times, 6/20).
Mental Health

Having Fun Whilst Burning Calories With Free Walk n' Play

What can"t the iPhone do? Now, thanks to a University of Houston professor, it can even count how many calories you"ve burned in a given day. A new, free download called Walk n" Play is available from Apple"s "App Store" that allows users to have fun while burning calories. The game lets players keep track of their physical activity through their iPhones and already has 3,000 users to date. Walk n" Play was designed by a team of researchers from UH"s Computational Physiology Lab led by Ioannis Pavlidis, Eckhard Pfeiffer Professor of Computer Science and the lab"s director. Co-developers include post-doctoral researcher Pradeep Buddharaju and doctoral student Yuichi Fujiki. Ergun Akleman from Texas A&M University designed the cartoon characters of the game. Debuting in March and now released in an updated, improved version today, Walk n" Play allows players to compete in real time against another iPhone user or against a simulator and watch the calories burn off as they go about their everyday walking. "You just keep the phone attached to your waistband or carry in your pocket as you normally would, and it records every little motion you do - from walking to climbing stairs - and translates it into calories burned," Pavlidis said. "The game operates on a 24-hour cycle and tallies everything up daily." While similar devices, such as pedometers, are nothing new, this iPhone application is unique in many respects. Pedometers, for example, communicate measures with such things as steps. Calories, however, are metabolic units and are the best measure of physical activity. For instance, a step taken by a 200-pound person is very different in terms of physical activity than a step taken by a 140-pound person. Boiling it down to simple mechanics, you need more energy to move a bigger mass. The game also has an advantage over treadmills, which measure a user"s activity confined in space and time. Walk n" Play allows using the world as a treadmill, Pavlidis said, typically giving a more accurate calorie count. A defining characteristic of Walk n" Play is the gaming or competition aspect. You are able to either employ the buddy system, commonly used in an exercise regimen, with a friend who also carries an iPhone or challenge yourself with a simulator that is programmed to follow an ideal routine for maintaining or losing weight through healthy activities. By trying to outdo your friend or follow the simulator"s behavior patterns, there"s a built-in incentive with this program. Pavlidis likens it to a form of social networking, motivating users to walk and putting them in contact with others. "Modern conveniences have changed our way of life," Pavlidis said. "The basic idea behind the application we"ve developed is for people to get motivated and back to living more active lifestyles." A modern person"s daily routine is sedentary. People used to climb stairs, wash clothes by hand, walk to work or the grocery store and often worked in manufacturing or farming jobs that required manual labor. These physical activities added up and have all but disappeared, along with the ability to expend anywhere between 1,000 to 2,000 calories per day, according to Pavlidis. We don"t sweat through everyday tasks like we used to. Nowadays, a majority of people drive to work, sit in an office for eight hours, use elevators and then go back home to oftentimes sit in front of a TV. Even if you squeeze in a gym trip somewhere in between, going to work out for 30 minutes isn"t the same, Pavlidis said, because the tremendous energy imbalance cannot easily be undone. Many people assume food is the main culprit behind today"s obesity epidemic. Pavlidis asserts that this is not necessarily true, as we sit in our offices and on our couches storing calories away. He says activity is the key and hopes the Walk n" Play application will encourage people to get into the habit of walking more during the day by perhaps taking a walk during breaks at work, parking in a spot that"s a little farther from the office, using the stairs instead of the elevator and developing a habit of walking after meals. Real-time monitoring of physical activity and accurately measuring calories burned during movement is quite difficult, with the best way to do so being through a cardio-pulmonary instrument that determines the amount of oxygen consumed. This direct analog of one"s metabolic activity, however, would require a person to wear a gas mask wired to heavy equipment. In the lab, Pavlidis and his team found a way around this cumbersome set up, devising a method to correlate accelerometer values with virtual oxygen-consumption measurements to calibrate the iPhone to accurately measure calories burned. The National Center for Human Performance at the Texas Medical Center provided Pavlidis" team with subjects and space to execute this biomedical portion of the research. Tom Krouskop, a professor at the Baylor College of Medicine, is the lab"s director. The game was first tested in a windows-based PDA that did not have an accelerometer, so they had to build one communicating through a Bluetooth device. With a built-in accelerometer that senses motion and can be made to measure metabolic activity, the iPhone was the next logical step for Walk n" Play. Once Pavlidis" group had a working prototype on the iPhone, they made it available for free download at Apple"s "App Store" in March. Just two months later, they have released a second version that is radically improved on many fronts. Most notably, it is now more user-friendly and the game recognizes more activity modes matched with appropriate animation to reflect walking and resting more realistically and accurately. Users also can now graphically choose the part of the body where they usually wear the iPhone, which is important for the accuracy of the calorie calculation. Most of the improvements were in response to feedback from dedicated users. The next phase of the program, pending approval from the university"s institutional review board, will seek volunteers among users to keep track of their data anonymously for a time period. Pavlidis said such large-scale monitoring of physical activity patterns will enable accurate mathematical modeling that is useful in researching obesity, energy consumption and massive emergency response. "It"s a pleasure applying our research to this sort of thing, because we can see immediate impact on everyday people," Pavlidis said. "It"s a revolutionary paradigm shift of how we can conduct research on a massive scale while doing some good." Lisa Merkl University of Houston


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