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Glenmark's Novel Molecule For Diabetes, Melogliptin To Enter Phase III Trials
In the recently completed 12 week Phase IIb clinical trial in 494 patients with type 2 diabetes mellitus (T2DM), "Melogliptin", Glenmark"s investigational medicine from a new class of diabetes treatments called dipeptidyl peptidase 4 (DPP-4) inhibitors, improved glycemic control in patients with type 2 diabetes mellitus and exhibited excellent safety and tolerability profile. In addition, patients taking Melogliptin experienced low incidence of hypoglycemia and neutral effect on body weight.
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Children's Hospital Oakland Scientists First To Discover New For Harvesting Stem Cells
A groundbreaking study conducted by Children"s Hospital & Research Center Oakland is the first to reveal a new avenue for harvesting stem cells from a woman"s placenta, or more specifically the discarded placentas of healthy newborns. The study also finds there are far more stem cells in placentas than in umbilical cord blood, and they can be safely extracted for transplantation. Furthermore, it is highly likely that placental stem cells, like umbilical cord blood and bone marrow stem cells, can be used to cure chronic blood-related disorders such as sickle cell disease, thalassemia, and leukemia.
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Bike Paths, Other 'Healthy' Infrastructure Projects Proving Controversial
"Attempts to set billions aside for infrastructure projects like bike paths face an uphill battle on Capitol Hill," The Chicago Tribune reports, adding "GOP legislators see no health savings in parks and similar projects," while advocates say preventive efforts will bring down costs. "A draft Senate bill would provide up to $10 billion annually for a "prevention and public health investment fund" -- a portion of which could be used for projects such as bike paths, sidewalks, farmers markets and other community interventions meant to curb chronic and costly conditions like obesity."
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Newsweek, Boston Globe Examine Ways To Combat Mosquito-Borne Illness

Newsweek Examines Efforts To Stop Disease Spread By Genetically Modifing Mosquitoes Newsweek examines the genetic modification of mosquitoes in an effort to stem the spread of dengue fever and malaria. Dengue fever, which is transmitted by the Aedes Aegypti mosquito, "is spreading fast," according to the magazine, with more than 100 million people afflicted yearly. "There is no vaccine, no cure and no solution," it reports. According to Newsweek, researchers "have devised a genetic modification that sterilizes the male Aedes, transforming the critter into his own worst enemy. He can still mate - but he can"t breed." Scientists are also looking into ways of "tweaking the genome of the Anopheles gambiae mosquito, the species that carries the malaria parasite, which kills at least a million people each year." The idea of genetically modified mosquitoes isn"t new, "[b]ut it"s only recently gained the support of mainstream health officials," and the Bill & Melinda Gates Foundation has invested $38 million into the research, Newsweek writes. Nonetheless, some environmental groups are raising issues, believing that "any tinkering with the world"s delicately balanced ecosystems is unacceptable," according to the magazine (Underhill, Newsweek, 6/27). Boston Globe Columnist Looks At DDT Home Spraying Debate In Uganda Boston Globe columnist Derrick Jackson looks at household DDT spraying in Uganda to battle malaria, where the country"s vice president, Gilbert Bukenya, recently said of the pesticide"s critics, "You can start with [spraying] my house. Those shouting against it are shouting ignorance. They are simply not informed."" Jackson writes that "the issue arouses great passion in sub-Saharan Africa, where access to the best drugs is woeful, and where simple home protections, such as window screens, are lacking." Jackson interviews regional malaria control director, Abwang Bernard, who said, "I understand the environmental arguments, but sometimes they cry so much fear, their arguments become inhuman to the people. It"s almost like they want the people to perish for the animals. No chemical has no side effects. But let us first reduce infant mortality. That is the environment I care about right now."" Bernard also discusses the challenges of using insecticide treated nets in Uganda (Jackson, Boston Globe, 6/27). This information was reprinted from globalhealth.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Global Health Policy Report, search the archives and sign up for email delivery at globalhealth.kff.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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