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Protecting The Heart With Glucocorticoid Drugs
Glucocorticoids are steroid hormones that have numerous functions; for example, they regulate the response to stress and suppress inflammation. Synthetic glucocorticoids are used clinically in many situations, most famously to treat asthma, allergies, and autoimmunity. They have also been shown in animals and humans to help protect the heart from the damaging effects of heart attack, and this has been attributed to their anti-inflammatory effects. However, Motoaki Sano and colleagues, at Keio University School of Medicine, Japan, have now determined another mechanism by which glucocorticoids protect rodent hearts from the damaging effects of heart attack. Specifically, glucocorticoids, acting via the glucocorticoid receptor (GR), induced mouse and rat heart muscle cells to produce PGD2, and this was responsible for the ability of glucocorticoids to reduce damage to mouse hearts in both an ex vivo and an in vivo model of heart attack. The authors therefore suggest that GR-selective glucocorticoids might be more beneficial to humans following heart attack than glucocorticoids that activate both GR and the MR protein, activation of which occurs in response to stress and might have unwanted consequences.
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Condoms Associated With Moderate Protection Against Herpes Simplex Virus 2
Condom use is associated with a reduced risk of contracting herpes simplex virus 2, according to a report based on pooled analysis of data from previous studies in the July 13 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
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Bacterial 'Sex' Causes Antibiotic Resistance
Some disease-causing bacteria are becoming resistant to antibiotics because they have peculiar sex lives, say researchers publishing new results in the journal Science. The new study helps scientists understand how bacteria develop resistance to antibiotics, which is a major challenge for those treating infectious diseases, say the authors from Imperial College London.
Mental Health

Parents Struggle With Costs Of Their Children's Autism Care

The total cost for treating a child with autism can reach $5 million, but insurance companies rarely cover autism therapy and few states mandate it. CBS News reports that "an estimated one in every 150 children in America has autism and the number of reported cases is growing" while "parents are increasingly demanding that insurance companies cover the newest treatment." CBS reports on the Oldham family in Virginia and how the parents Cassandra and Bill Oldham are dealing with the autism of Gareth and Korlan, two of their three children. CBS reports: "The emotional anguish was multiplied by financial stress." "Intensive, one-on-one behavioral and speech therapy called "applied behavior analysis therapy" or ABA helps the boys. But it costs up to $7,000 a month per child for the recommended 40 hours per week. The Oldhams struggled to pay even half the amount." The family has insurance, "but not for autism therapy because Virginia isn"t one of the seven states that mandate coverage. Businesses say adding autism to the list is too expensive." Cassandra Oldham and state Delegate Bob Marshall "are pushing legislation that would force insurers to cover ABA, and say the costs of a policy would be minimal - somewhere between $2 and $4 a month" (Assuras, 6/21). This information was reprinted from kaiserhealthnews.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Health Policy Report, search the archives and sign up for email delivery at kaiserhealthnews.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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