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Targacept Announces Decision By AstraZeneca To Advance AZD3480 Program In ADHD
Targacept, Inc. (NASDAQ: TRGT), a clinical-stage biopharmaceutical company developing a new class of drugs known as NNR Therapeutics (TM), announced that AstraZeneca has informed Targacept that it plans to conduct further development of AZD3480 (TC-1734) for attention deficit/hyperactivity disorder (ADHD) and has agreed to make a $10 million milestone payment to Targacept.
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Obesity Is A Poor Gauge For Detecting High Cholesterol Levels In Children
With the epidemic of childhood obesity in the United States, there is concern that overweight and obese children need to be screened for chronic medical conditions, including high cholesterol levels.
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Amicus Therapeutics Commences Phase 3 Trial Evaluating Amigal(TM) For The Treatment Of Fabry Disease
Amicus Therapeutics (Nasdaq: FOLD) announced it has commenced the U.S. registration Phase 3 trial with its investigational drug, Amigal(TM) (migalastat hydrochloride) for the treatment of Fabry disease. The Company has reached agreement with the U.S. Food and Drug Administration (FDA) on the key protocol design elements of the pivotal trial, including the use of the surrogate primary endpoint of the change in the amount of kidney interstitial capillary GL-3, the substrate that accumulates in the cells of Fabry patients. In addition, the FDA is in agreement that the Company is eligible to seek Accelerated Approval for Amigal according to Subpart H regulations. The Company has begun submitting the Phase 3 protocol to investigational sites worldwide and expects to begin the dosing of subjects in the second half of this year.
Endocrinology

Quality Data Made Accessible To Clinical Teams

NHS clinical teams will have access to data showing their performance against a set of more than 200 indicators of high quality care in the NHS in one place. It is the next phase in the drive to help NHS professionals improve the quality of care they deliver to patients, and will also support providers and commissioners of NHS services. The Department of Health and The NHS Information Centre have made the data available to allow NHS professionals to use it as a basis to assess local quality improvement. They form an easily accessible menu for NHS staff to carry out local analysis and comparisons between NHS organisations. The Indicators for Quality Improvement (IQI) have been selected in conjunction with the Royal Colleges, following extensive consultation with the NHS, and are currently based on existing national indicator sets and data collections. Over the next three to five years, the coverage of these will be expanded to more comprehensively address the wide range of NHS and Social Care services NHS professionals provide. Health Minister, Lord Darzi said: "These quality indicators have been developed in partnership with frontline staff. This initial list is just the start of a NHS wide re that will challenge and stimulate NHS staff to drive up the quality of care they deliver to patients. Throughout my career as a surgeon I have seen the value of having reliable data which allows clinical teams to asses the quality of the service they provide and to constantly challenge themselves to improve. I would encourage all clinicians to visit this site and to begin to use the data to drive up the quality of the services they provide." Some of the data for the indicators in the IQI is already available to the public on the NHS Choices website. Over the coming year, the intention is to also make the majority of the remainder available on the NHS Choices website. The NHS Information Centre website, targeted at NHS professionals, will today make the data available for more than 75% of the indicators, with the remainder to follow shortly. The indicators can be found at http://www.ic.nhs.uk/mqi Department of Health, UK


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