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Randomized Controlled Trial Shows Circumcision Does Not Reduce Male-To-Female HIV Transmission
Male circumcision does not reduce the transmission of HIV from men to their female partners, according to a Lancet study conducted in Uganda, Bloomberg reports (Sargent, 7/16). The researchers recruited 922 uncircumcised HIV-positive men between the ages of 15 and 49 for the study, who were then divided into two groups - those who were "immediately circumcised" and those for whom the procedure was "delayed for two years" Reuters reports. Researchers also followed the wives and female sex partners of the men, who all were HIV-negative (Fox, 7/16). The analysis found that "18 percent of the female partners of the circumcised men became infected with the virus compared with 12 percent of the partners of men who hadn"t undergone the procedure," Bloomberg writes (7/16). Despite studies that "suggested circumcision ò€¦ can lower the rate of male-to-female virus transmission from HIV-positive men" the researchers concluded that "[c]ircumcision of HIV-infected men didn"t reduce HIV transmission to female partners over 24 months; longer-term effects could not be assessed" (Wawer et al., Lancet, July 2009).
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Genome Biology And Evolution: After Dinosaurs, Mammals Rise But Their Genomes Get Smaller
Evidence buried in the chromosomes of animals and plants strongly suggests only one group -- mammals -- have seen their genomes shrink after the dinosaurs" extinction. What"s more, that trend continues today, say Indiana University Bloomington scientists in the first issue of a new journal, Genome Biology and Evolution.
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Franken To Be Seated As Minn. Senator, Will Serve On HELP, Judiciary Committees
The Minnesota Supreme Court on Tuesday unanimously voted to uphold Al Franken"s (D) win in the 2008 U.S. Senate election in Minnesota, effectively clearing the way for Franken to become the state"s newest senator, the Wall Street Journal reports. His election gives Democrats in the Senate a 60-vote supermajority, which could help the party pass health care reform legislation, according to the Journal. Following the ruling, opponent Sen. Norm Coleman (R-Minn.) conceded the election, and Minnesota Gov. Tim Pawlenty (R) said that he would certify the result Tuesday.Franken is expected to be seated next week. He will join the Senate Judiciary Committee, where he will vote on the Supreme Court nomination of Judge Sonia Sotomayor, and the Senate Health, Education, Labor and Pensions Committee, which is completing its draft of health care reform legislation (Bendavid/Hitt, Wall Street Journal, 7/1).
Mental Health

Successful Neurosurgery With Transcranial MR-guided High-Intensity Focused Ultrasound

The Magnetic Resonance Center of the University Children"s Hospital Zurich has achieved a world first break through in MR-guided, non-invasive neurosurgery. Ten patients have been successfully treated by means of transcranial high-intensity focused ultrasound. This fully non-invasive procedure opens new horizons for neurosurgery and the treatment of different neurological brain disorders. In the context of a clinical study at the MR Center of the University Children"s Hospital Zurich transcranial MR-guided high-intensity focused ultrasound (HIFU) for brain surgery has been successfully applied for the first time world-wide. A research team under the direction of Professor Daniel Jeanmonod, neurosurgeon at the Department of Functional Neurosurgery of the Neurosurgical Clinic at the University Hospital Zurich and Professor Ernst Martin, director of the Magnetic Resonance Center at the University Children"s Hospital Zurich succeeded in proving the safety and efficacy of this revolutionary surgical method which permits fully non-invasive brain interventions even on an out-patient basis. For quite some years, HIFU has been used for the treatment of uterine fibroids and tumors of the prostate gland. However, its application to the brain through the intact skull for non-invasive neurosurgery was not possible until recently, because of insurmountable technical difficulties. Non-invasive neurosurgery In a Swiss National research project, the team of the University of Zurich successfully implemented and optimized a prototype system for transcranial Magnetic Resonance-guided High-Intensity Focused Ultrasound (HIFU) for neurosurgical interventions. The HIFU system ExAblate® 4000, developed by the cooperation partner InSightec, Tirat Carmel Israel, has been combined with a 3 Tesla high field GE MR-scanner. The two systems together provide a platform for image-guided, non-invasive interventions. Since September 2008 ten patients were treated at the Children"s Hospital Zurich with this new neurosurgical procedure in the context of a clinical study. All interventions were completed successfully and without complications. This novel technology now opens up new horizons allowing to develop non-invasive intervention procedures for a variety of brain diseases including brain tumors. The whole surgical procedure is planned and monitored in real time by magnetic resonance imaging (MRI). The HIFU beams produced by 1024 transducers are transferred through the intact skull of the patient into the brain and concentrated onto a focus of 3 to 4 millimeters in diameter. Thus, sharply defined targets deep inside the brain are coagulated by heating them up to a focal temperature of 60 degrees Celsius. The temperature increase during the sequential ò€žsonications", each lasting 10 to 20 seconds, is continuously displayed and controlled on precise MR-temperature distribution maps. The whole surgical procedure lasts several hours and is performed without anaesthesia. Patients are awake and fully conscious during the intervention. A project of the National Centre of Competence in Research (NCCR) Co-Me In the context of the Swiss National Research Program NCCR Co-Me (computer aided and image guided medical interventions), the potential of non-invasive, transcranial MR-guided high-intensity focused ultrasound (tcMRgHIFU) is investigated in clinical studies at the University Children"s Hospital Zurich. Scientists working in the Co-Me program pursue the goal of establishing and developing surgical interventions by means of tcMRgHIFU, in order to broaden the spectrum of completely non-invasive interventions for functional neurosurgery and for the treatment of brain tumors, stroke and various neurological brain disorders by targeted drug delivery. The research project represents a co-operation between the University of Zurich and the ETH Zurich, through (A) the Magnetic Resonance Center of the University Children"s Hospital (Professor Ernst Martin), (B) the Department of Functional Neurosurgery of the Neurosurgical Clinic at the University Hospital Zurich (Professor Daniel Jeanmonod), (C) the Medical Image Analysis and Computer Vision Laboratory of the ETH Zurich (Professor Gabor SzÓ©kely) and (D) the Institute of Neuroinformatics, ETH Zurich (PD Dr. Daniel Kiper), as well as the industrial partner InSightec Ltd. Zurich University


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