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Nox(4)ious Requirement In Common Infant Tumor
Hemangiomas are the most common tumor of infancy. They are benign tumors derived from cells that line blood vessels (endothelial cells) and spontaneously regress as a child gets older. Jack Arbiser and colleagues, at Emory University School of Medicine, Atlanta, have now provided new insight into the molecules that control hemangioma growth and found that inhibiting a key molecule substantially inhibits hemangioma growth in a mouse model. Specifically, the protein Nox4 was found to be crucial for hemangioma growth in a mouse model and the drug fulvene 5 was found to be a potent in vitro inhibitor of Nox4 and to substantially inhibit in vivo hemangioma growth. The authors therefore suggest that targeting Nox4, potentially using fulvene derivatives, might provide a way to attenuate hemangioma growth.
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Study Estimates Cost Added To Private Health Insurance Premiums To Cover Uncompensated Care
The average U.S. family and their employers paid an additional $1,017 in health care premiums in 2008 to pay for care of the uninsured, according to a study released on Thursday by Families USA, USA Today reports (Kim, USA Today, 5/28). According to the study, which examined federal data, the uninsured received $116 billion in health care from hospitals, physicians and other providers in 2008 and paid 37% of that amount. Government programs and charities covered an additional 26%, which left another 37%, or about $43 billion, unpaid. The study then estimated how those costs are when spread across the insured through higher premiums, the study found. According to the study, prepared by the actuarial firm Milliman, the average additional amount paid under private coverage for single individuals was about $370 per year (Werner, AP/Austin American-Statesman, 5/28). Families USA Executive Director Ron Pollack said, "This is a hidden tax on all insurance premiums, whether it is paid by business for their work or by families when they purchase their own coverage" (USA Today, 5/28).The study is available online.
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Pirfenidone May Help Lung Function In IPF Patients According To Large Clinical Trial
A large, well-controlled, multi-national clinical trial program has demonstrated the effectiveness and safety of what may become the first FDA-approved medicine for idiopathic pulmonary fibrosis, or IPF.
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Teach Your Patients About Their Medicines To Avoid Misadventure, UK

The National Prescribing Service Ltd (NPS) is urging health professionals to teach patients how to identify the active ingredient in their medicines to avoid mix ups and adverse events. A recent NPS literature review found six per cent of hospitalisations are due to adverse events, which increases to nearly 30 per cent in the elderly. Past studies have confirmed that many hospitalisations due to adverse events could have been avoided if the patient had understood their medicines. "Some people identify their medicines by colour and shape, which gets them in trouble if they have to switch brands," NPS CEO, Dr Lynn Weekes said. "There are numerous anecdotes about patients who thought a different brand was a completely different medicine and took both, or stopped taking the medicine completely because they didn"t know what it was." "GPs and pharmacists are trusted experts and are well placed to teach people how to read and understand their medicine labels. To help you do this, NPS has developed several tools that can be used in any pharmacy or GP clinic," Dr Weekes said. These include the NPS Medicine Name Finder, which is an online tool that identifies the active ingredient in PBS-listed prescription medicines and their alternate brand names, and a Medicines List. When a brand name is entered into the NPS Medicine Name Finder, the active ingredient appears and when the active ingredient is entered all available brand names appear. Users are then prompted to record their medicine details on a downloadable Medicines List or print the information to discuss it with their health professional. A link is also provided to the Consumer Medicine Information (CMI) leaflet which contains more details about the medicine. Medicines Lists provide a standard template for recording the necessary information about a patient"s current medicines - names, dosage, dosing frequency and indications - in one simple document they can carry around and update as necessary. "Demonstrating these tools to your patients will not only ensure they understand what they are taking but also provide a check for the health professional to ensure they know what has been prescribed and dispensed," Dr Weekes said. Medicines Lists and the NPS Medicine Name Finder are available to download for free at www.nps.org.au/activeingredient. The Medicine Name Finder can also be saved as a Google Gadget for fast, easy use if you have an iGoogle account. The National Prescribing Service Limited


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